One article tells what is the milk thistle extract(Silymarin)?

1, Description

The Milk Thistle Extract is a standardized herbal extract of the fruits of Silybum marianum (L.) Gaertn.

Silymarin is considered to be the main component of milk thistle seeds, but the terms “milk thistle” and “silymarin” often are used interchangeably.

Historically, people have used milk thistle for liver disorders, such as hepatitis and cirrhosis, and gallbladder problems.

Silymarin is the most commonly used herbal supplement in the United States for liver problems.

Milk thistle products are available as capsules, powders, and extracts.

The Milk Thistle Extract is an herbal preventive and therapeutic agent against metabolic liver diseases.

The therapeutic effect is based on

– Stimulation of RNA polymerase I in livercells

– Stabilization of livercell membranes – Antioxydative properties

The Milk thistle extract protects liver cells both directly and indirectly. It also possesses the unique ability to regenerate liver cells that have been injured.

There are no reports on interaction of milk thistle extract with other drugs.

2. Chemistry

Milk thistle contains several groups of substances:

Flavonolignans: Silymarin an isomer mixture of the flavonolignans silybin, silychristin and silydianin and other flavonolignans like isosilybin, isosilichristin, dehydrosilibin and dehydrosilichristin.

Flavonoids: apigenin, eriodictyol, chrysoeriol, 5,7-dihydroxychromone, dihydrokaempferol, isofraxidin, naringenin, quercetin and taxifolin.

Neolignan: dehydrodiconiferyl alcohol.

Aliphatic oil: a high proportion of linoleum acid, oleic acid and palmitic acid as well as some other fatty acids together with tocopherol and sterols such as campesterol, cholesterol, sitosterol and stigmasterol.

3. Indications and Therapeutic Safety

The extract of milk thistle is used in the treatment of toxic liver damage and is also recommended for supportive treatment of chronic inflammatory liver diseases and cirrhosis. The therapeutic effect is based on the stimulation of RNA polymerase I in liver cells,

the stabilisation of liver cell membranes and its antioxydative properties. Milk thistle possesses the ability to regenerate liver cells that have been injured.

Milk thistle extract is generally well tolerated. Side-effects are rare when the standardised

extract is taken. There are no known interactions with drugs usually prescribed.

Milk thistle extract is notable of its particularly high level of clinical safety. It is almost devoid of any side-effects and may be used by a wide range of people. Since it does stimulate liver and gallbladder activity, it may have a mild, transient laxative effect in some individuals.

4.Raw material(Milk Thistle Seed) in China.

Milk Thistle is originate in German, In 1972, It is planted in China. Milk Thistle Seed is cultivated in northeast of China, Liaoning province, Heilongjiang province, and Inner Mongolia. The harvest season is the late August and September every year. The crop yield is around 60 000mt to 80 000mt these years.

What major weather events that may affect output:

Milk thistle is resistant to cold, and dry. It is not strict on the soil. It can be planted in general soil, but it is afraid of waterlogging, so it cannot be planted in low-lying waterlogged land, otherwise it will lead to uneven emergence and reduced yield.

5, The output of silymarin in China.

As we survey from the main manufacturers in China and the China customs, the total amount of silymarin in China is roughly 2000mt.

The largest country of export destination is US, then German, India, Spain, Korea.

The Asia-Pacific region is growing fastest.

6,The common specification in the market.

Products nameSpecification
SilymarinUV80%
UV80%HPLC40%
UV80%HPLC45%Silybin+Isosilybin30%
UV80%HPLC50%Silybin30%
UV85%HPLC55%Silybin35%
UV85%HPLC58%
UV85%HPLC60%
  SilybinHPLC80%
Silybin 80%
Silybin 90%
Silybin 95%
Silybin 98%

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